A new rheumatic heart disease treatment is set to be trialled in WA, where the condition affects Indigenous people.

The Telethon Kids Institute says it hopes Australian patients can benefit from penicillin injections into abdominal tissue.

Trials in New Zealand have reported the alternative treatment to intramuscular injections is less painful.

Infectious diseases physician Laurens Manning told the ABC a community-led trial could be rolled-out in the Kimberley.